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| http://purl.uniprot.org/citations/27570074 | http://www.w3.org/2000/01/rdf-schema#comment | "ER-associated degradation (ERAD) is essential for protein quality control in the ER, not only when the ER is stressed, but also at steady state. We report a new layer of homeostatic control, in which ERAD activity itself is regulated posttranscriptionally and independently of the unfolded protein response by adjusting the endogenous levels of EDEM1, OS-9, and SEL1L (ERAD enhancers). Functional UBC6e requires its precise location in the ER to form a supramolecular complex with Derlin2. This complex targets ERAD enhancers for degradation, a function that depends on UBC6e's enzymatic activity. Ablation of UBC6e causes upregulation of active ERAD enhancers and so increases clearance not only of terminally misfolded substrates, but also of wild-type glycoproteins that fold comparatively slowly in vitro and in vivo. The levels of proteins that comprise the ERAD machinery are thus carefully tuned and adjusted to prevailing needs."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.07.014"xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/author | "Ling J."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/author | "Hagiwara M."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/author | "Koenig P.A."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/pages | "753-767"xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/title | "Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e."xsd:string |
| http://purl.uniprot.org/citations/27570074 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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