| http://purl.uniprot.org/citations/27578456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27578456 | http://www.w3.org/2000/01/rdf-schema#comment | "STAT4 is critical for the production of IFN-γ during the generation of Th1 immune responses. We investigated the role of STAT4 in mediating Th1-inducing activity of a vaccine adjuvant monophosphoryl lipid A (MPL-A) using the standard antigen ovalbumin (OVA) in STAT4KO mice. Our results show that splenocytes from STAT4KO mice displayed lower OVA-specific T-cell proliferation and IL-2 production compared with wild-type (WT) mice. Further, IFN-γ production was diminished in STAT4KO-derived splenocytes but the levels of IL-12 and TNF-α were similar compared with WT mice. Interestingly, STAT4 deficiency also led to a decrease in IL-10 and Th2 cytokines such as IL-4 and IL-13 upon MPL-A immunization, although IL-17 production was similar between WT- and STAT4KO-derived splenocytes. Our observations for defective Th1 and Th2 responses in STAT4KO mice were further supported by the low levels of Th1-associated IgG2a and Th2-associated IgG1 in the sera of these mice. Taken together, our results show that STAT4 plays a critical role in mediating both Th1 and Th2 responses upon immunization with MPL-A. Our study provides a better understanding of how MPL-A mediates T-cell activation which will be critical for future vaccine development."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxw038"xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Kaplan M.H."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Moretti E."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Satoskar A.R."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Natarajan G."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Oghumu S."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Varikuti S."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/author | "Sperling R.H."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/pages | "565-570"xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/title | "STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity."xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/27578456 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27578456 |
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| http://purl.uniprot.org/uniprot/#_Q8C2A4-mappedCitation-27578456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27578456 |
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