| http://purl.uniprot.org/citations/27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27582468 | http://www.w3.org/2000/01/rdf-schema#comment | "DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decisions. Whereas effector function of DNMT3a knockout T cells is normal, they develop more memory precursor and fewer terminal effector cells in a T-cell intrinsic manner compared with wild-type animals. Rather than increasing plasticity of differentiated effector CD8(+) T cells, loss of DNMT3a biases differentiation of early effector cells into memory precursor cells. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1524490113"xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Li K.P."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Jaffee E.M."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Phillips M.J."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Haile A."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Powell J.D."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Hildeman D.A."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Gamper C.J."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Ladle B.H."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/author | "Pucsek A.B."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/pages | "10631-10636"xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/title | "De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation."xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27582468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27582468 |
| http://purl.uniprot.org/citations/27582468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27582468 |
| http://purl.uniprot.org/uniprot/#_A0A5K1VVQ7-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPS9-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |
| http://purl.uniprot.org/uniprot/#_G3UXY2-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |
| http://purl.uniprot.org/uniprot/#_G3UY43-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |
| http://purl.uniprot.org/uniprot/#_G3UZF8-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |
| http://purl.uniprot.org/uniprot/#_G3UZG8-mappedCitation-27582468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582468 |