| http://purl.uniprot.org/citations/27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27582470 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia patients, causing metabolic and epigenetic derangements. We have now discovered that altered metabolism in leukemic cells has a profound effect on cardiac metabolism. Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart. This contractile dysfunction is associated with impaired oxidative decarboxylation of α-ketoglutarate, a redirection of Krebs cycle intermediates, and increased ATP citrate lyase (ACL) activity. Increased availability of D2-HG also leads to altered histone methylation and acetylation in the heart. We propose that D2-HG promotes cardiac dysfunction by impairing α-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner. Collectively, our results highlight the impact of cancer cell metabolism on function and metabolism of the heart."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1601650113"xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Wang J.H."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Taegtmeyer H."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Goodell M.A."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Harmancey R."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Vasquez H."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Vitrac H."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/author | "Karlstaedt A."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/pages | "10436-10441"xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/title | "Oncometabolite d-2-hydroxyglutarate impairs alpha-ketoglutarate dehydrogenase and contractile function in rodent heart."xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27582470 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27582470 |
| http://purl.uniprot.org/citations/27582470 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27582470 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP68-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_P54071-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPR1-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_D6RIL6-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_Q60597-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_Q5SVY0-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |
| http://purl.uniprot.org/uniprot/#_Q5SVY1-mappedCitation-27582470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27582470 |