| http://purl.uniprot.org/citations/27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27587396 | http://www.w3.org/2000/01/rdf-schema#comment | "The aggregation of α-synuclein (α-syn) into amyloid fibrils is associated with neurodegenerative diseases, collectively referred to as the α-synucleinopathies. In vivo, molecular chaperones, such as the small heat-shock proteins (sHsps), normally act to prevent protein aggregation; however, it remains to be determined how aggregation-prone α-syn evades sHsp chaperone action leading to its disease-associated deposition. This work examines the molecular mechanism by which two canonical sHsps, αB-crystallin (αB-c) and Hsp27, interact with aggregation-prone α-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of α-syn aggregation, but no stable complex between the sHsps and α-syn was detected, indicating that the sHsps inhibit α-syn aggregation via transient interactions. Moreover, the ability of these sHsps to prevent α-syn aggregation was dependent on the kinetics of aggregation; the faster the rate of aggregation (shorter the lag phase), the less effective the sHsps were at inhibiting fibril formation of α-syn. Thus, these findings indicate that the rate at which α-syn aggregates in cells may be a significant factor in how it evades sHsp chaperone action in the α-synucleinopathies."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.739250"xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/author | "Cox D."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/author | "Griffin M.D."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/author | "Carver J.A."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/author | "Ecroyd H."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/author | "Selig E."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/pages | "22618-22629"xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/title | "Small Heat-shock Proteins Prevent alpha-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation."xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27587396 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27587396 |
| http://purl.uniprot.org/citations/27587396 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27587396 |
| http://purl.uniprot.org/uniprot/#_A0A024R3B9-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_A0A140G961-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HU10-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_B4DIA6-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_C3VMY8-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_H6UYS7-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_H6UYS0-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_H6UYS5-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_F6L6N6-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |
| http://purl.uniprot.org/uniprot/#_P37840-mappedCitation-27587396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27587396 |