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Background

Hepatocellular carcinoma (HCC) is associated with inflammation, and roughly 30 % of the global population shows serological evidence of current or past infection with hepatitis B or hepatitis C virus. Resident hepatic macrophages, known as Kupffer cells (KCs), are considered as the specific tumor-associated macrophages (TAMs) of HCC, and can produce various cytokines-most importantly interleukin (IL)-6-to promote tumorigenesis of HCC. However, the roles of KCs and IL-6 in carcinogenesis in the liver are still unclear.

Methods

We analyzed leukocyte-related peripheral blood data of 192 patients and constructed a mouse model in which the bone marrow was cleared out by irradiation and reconstructed using bone marrow donated from IL-6-deficient mice to further elucidate the hepatic pathological changes in response to toxic challenge and oncogenic gene mutation.

Results

Peripheral monocyte counts and serum IL-6 levels were significantly higher in patients with HCC than in those without HCC. In addition, there was a significant difference in the levels of IL-6 among individuals with different histopathological grades. In mice with selective IL-6 ablation in monocytes/KCs, we observed decreased toxic liver injury, inflammatory infiltration, and systemic inflammation. In Mdr2-deficient mice, which spontaneously developed HCC, the loss of IL-6 in monocytes/KCs resulted in inhibition of IL-6/signal transducer and activator of transcription 3 signaling, decreased serum IL-6 levels, and delayed tumorigenesis.

Conclusions

Our findings demonstrate that increased TAM-derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of HCC."xsd:string
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http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Kong L."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Shi Y."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Yang J."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Zhou Y."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Lv T."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/author"Bu H."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/name"J Exp Clin Cancer Res"xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/pages"131"xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/title"Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice."xsd:string
http://purl.uniprot.org/citations/27589954http://purl.uniprot.org/core/volume"35"xsd:string
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