| http://purl.uniprot.org/citations/27592451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27592451 | http://www.w3.org/2000/01/rdf-schema#comment | "KLF10 is a transforming growth factor (TGF)-β/Smad downstream regulated gene. KLF10 binds to the promoter of target genes and mimics the effects of TGF-β as a transcriptional factor. In our laboratory, we noted that Klf10 deficiency in mice is associated with significant inflammation of the lungs. However, the precise mechanism of this association remains unknown. We previously identified NPRA as a target gene potentially regulated by KLF10 through direct binding; NPRA knockout have known that prevented lung inflammation in a mouse model of allergic asthma. Here, we further explored the regulatory association between KLF10 and NPRA on the basis of the aforementioned findings. Our results demonstrated that KLF10 acts as a transcriptional repressor of NPRA and that KLF10 binding reduces NPRA expression in vitro. Compared with wild-type mice, Klf10-deficient mice were more sensitive to lipopolysaccharide or ovalbumin challenge and showed more severe inflammatory histological changes in the lungs. Moreover, Klf10-deficient mice showed pulmonary neutrophil accumulation. These findings collectively reveal the precise site where KLF10 signaling affects pulmonary inflammation by attenuating NPRA expression. They also verify the importance of KLF10 and atrial natriuretic peptide/NPRA in exerting influences on chronic pulmonary disease pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2016.08.027"xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Chang H.W."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Wu M.J."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Lai Y.T."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Yu W.C.Y."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Wu W.C."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Huang L.T."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/author | "Chang V.H.S."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/pages | "231-238"xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/title | "Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA."xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/27592451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27592451 |
| http://purl.uniprot.org/citations/27592451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27592451 |
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