| http://purl.uniprot.org/citations/27596722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27596722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27596722 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein-protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the stabilization of α-helices, which limits their general applicability. Here we report for the first time on the use of ring-closing alkyne metathesis for the stabilization of an irregular peptide secondary structure. A small library of alkyne-crosslinked peptides provided a number of derivatives with improved target affinity relative to the linear parent peptide. In addition, we report the crystal structure of the highest-affinity derivative in a complex with its protein target 14-3-3ζ. It can be expected that the alkyne-based macrocyclization of irregular binding epitopes should give rise to new scaffolds suitable for targeting of currently intractable proteins."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbic.201600362"xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbic.201600362"xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Ottmann C."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Ottmann C."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Grossmann T.N."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Grossmann T.N."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Glas A."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Glas A."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Bier D."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Bier D."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Cromm P.M."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Cromm P.M."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Furstner A."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Furstner A."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Wallraven K."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/author | "Wallraven K."xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/name | "ChemBioChem"xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/name | "Chembiochem"xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/pages | "1915-1919"xsd:string |
| http://purl.uniprot.org/citations/27596722 | http://purl.uniprot.org/core/pages | "1915-1919"xsd:string |