Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27611173http://www.w3.org/2000/01/rdf-schema#comment"

Background

Type 1 diabetes (T1D) is thought to involve chronic inflammation, which is manifested by the activation and expression of different inflammatory mediators. Th1- and Th17-associated cytokines are factors that have been shown to exert profound pro-inflammatory activities and have been implicated in the pathogenesis of T1D in mice and humans.

Objectives

Therefore, the aim of this case control study was to determine the serum level of IL-17, IL-21, IL-27, transforming growth factor beta (TGF-β), and IFN-γ and their reciprocal relationship in Iranian T1D patients.

Patients and methods

Blood samples were collected from 48 T1D patients and 49 healthy individuals with no history of malignancies or autoimmune disorders based on simple sampling. The serum levels of IL-17, IL-21, IL-27, TGF-β, and IFN-γ were measured by the enzyme linked immunosorbent assay (ELISA).

Results

The serum levels of IL-17 and IL-21 were significantly higher in T1D patients compared to the healthy individuals (p = 0.005 and 0.01, respectively), but interestingly, the opposite was the case for IL-27 (p < 0.0001). However, there were no significant differences in TGF-β and IFN-γ between both groups. In addition, IL-17/IFN-γ and IL-17/IL-27 ratios were higher in patients compared to the control group.

Conclusions

Our results indicated dominant Th17-associated IL-17, suggesting a shift from the Treg and Th1 phenotypes toward the Th17 phenotype. Therefore, it can promote inflammation in β cells in T1D. In addition, it suggests the role of Th17 and Th17/Th1 ratios as a potential contributor to β cells destruction and the Th17/Th1 response ratio may provide a novel biomarker for rapid T1D diagnosis before the destruction of β cells and progression of the disease to the clinical end stages."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.org/dc/terms/identifier"doi:10.1080/08820139.2016.1197243"xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Sadeghi A."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Davami M.H."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Faraji F."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Baharlou R."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Ahmadi-Vasmehjani A."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Asadi M.A."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Atashzar M.R."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Karimipour F."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/author"Khoubyari M."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/name"Immunol Invest"xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/pages"641-651"xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/title"Elevated Levels of T-helper 17-associated Cytokines in Diabetes Type I Patients: Indicators for Following the Course of Disease."xsd:string
http://purl.uniprot.org/citations/27611173http://purl.uniprot.org/core/volume"45"xsd:string
http://purl.uniprot.org/citations/27611173http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27611173
http://purl.uniprot.org/citations/27611173http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27611173
http://purl.uniprot.org/uniprot/#_D9MX03-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
http://purl.uniprot.org/uniprot/#_A0A224B028-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
http://purl.uniprot.org/uniprot/#_Q5QEX9-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
http://purl.uniprot.org/uniprot/#_Q16552-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
http://purl.uniprot.org/uniprot/#_Q6NZ94-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
http://purl.uniprot.org/uniprot/#_Q9HBE4-mappedCitation-27611173http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27611173
▶