| http://purl.uniprot.org/citations/27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27611588 | http://www.w3.org/2000/01/rdf-schema#comment | "Lupus nephritis (LN) is a disease with a poor prognosis. The association between LN and the Human leukocyte antigen (HLA) genes has never been studied on a Moroccan population. The aim of this work was to evaluate the distribution of the HLA class II alleles in patients with LN and to determine susceptible and protective HLA alleles/haplotypes in LN. The association between these alleles, disease severity of LN, and age at onset were also investigated. Seventy-five patients with LN were compared with 169 healthy unrelated controls. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP). A significant increase of HLA-DRB1*15 allele frequency (p = 0.001) and a significant decrease of the HLA-DRB1*04 allele (p = 0.04) were observed in LN patients. The frequency of HLA-DRB1*15-DQB1*06 haplotype (p = 0.003) was increased in the patients while that of HLA-DRB1*04-DQB1*03 (p = 0.027) was decreased. A significant increase of HLA-DRB1*15 allele frequency (p = 0.0001) and HLA-DRB1*15-DQB1*06 haplotype (p = 0.002) was observed in patients with class IV LN. In the Moroccan population we demonstrated the positive association of HLA class II alleles and haplotypes with LN and with a severe form of nephritis. HLA-DRB1*15 allele does not determine the age of disease onset in LN."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.org/dc/terms/identifier | "doi:10.1080/08820139.2016.1208218"xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Ibrahimi A."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Essakalli M."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Benseffaj N."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Ouadghiri S."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Bayahia R."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Bhallil O."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/author | "Ouzeddoun N."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/name | "Immunol Invest"xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/title | "HLA Class II with Lupus Nephritis in Moroccan Patients."xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/27611588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27611588 |
| http://purl.uniprot.org/citations/27611588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-27611588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27611588 |