| http://purl.uniprot.org/citations/27617966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27617966 | http://www.w3.org/2000/01/rdf-schema#comment | "In a pilot ProtoArray analysis, we identified 6 proteins out of 9483 recognized by autoantibodies (AAb) from patients with systemic sclerosis (SSc). We further investigated the 6 candidates by ELISA on hundreds of controls and patients, including patients with Systemic Lupus Erythematosus (SLE), known for high sera reactivity and overlapping AAb with SSc. Only 2 of the 6 candidates, Ephrin type-B receptor 2 (EphB2) and Three prime Histone mRNA EXonuclease 1 (THEX1), remained significantly recognized by sera samples from SSc compared to controls (healthy or with rheumatic diseases) with, respectively, 34% versus 14% (P = 2.10-4) and 60% versus 28% (P = 3.10-8). Above all, EphB2 and THEX1 revealed to be mainly recognized by SLE sera samples with respectively 56%, (P = 2.10-10) and 82% (P = 5.10-13). As anti-EphB2 and anti-THEX1 AAb were found in both diseases, an epitope mapping was realized on each protein to refine SSc and SLE diagnosis. A 15-mer peptide from EphB2 allowed to identify 35% of SLE sera samples (N = 48) versus only 5% of any other sera samples (N = 157), including SSc sera samples. AAb titers were significantly higher in SLE sera (P<0.0001) and correlated with disease activity (p<0.02). We could not find an epitope on EphB2 protein for SSc neither on THEX1 for SSc or SLE. We showed that patients with SSc or SLE have AAb against EphB2, a protein involved in angiogenesis, and THEX1, a 3'-5' exoribonuclease involved in histone mRNA degradation. We have further identified a peptide from EphB2 as a specific and sensitive tool for SLE diagnosis."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0160283"xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Martin T."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Granel B."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Chiche L."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Roudier J."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Bardin N."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Hachulla E."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Harle J.R."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Dubucquoi S."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Martin G.V."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Lambert N.C."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Balandraud N."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Auger I."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Diot E."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Cabane J."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Tiev K."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Farge-Bancel D."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Azzouz D.F."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Kanaan S.B."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Arnoux F."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/author | "Caillet E.C."xsd:string |
| http://purl.uniprot.org/citations/27617966 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |