| http://purl.uniprot.org/citations/27619680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27619680 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited to primary tumours to compose the tumour microenvironment. In various cancers, CD133-positive cells have been shown to possess cancer stem cell properties that confer chemoresistance. This study aimed to investigate the role of BM-MSCs in the anti-tumour drug resistance of CD133-expressing gastric cancer cells and explore the underlying mechanisms that governing this role. We found that CD133+ gastric cancer cells displayed more resistance to chemotherapeutics than CD133- cells. In addition, BM-MSCs increased the anti-apoptotic abilities and chemoresistance of CD133+ cells via upregulation of Bcl-2 and downregulation of BAX. Mechanistically, BM-MSCs triggered activation of the PI3K/Akt signalling cascade in CD133+ cells. Blocking the PI3K/Akt pathway inhibited the promotion of chemoresistance. Furthermore, BM-MSCs enhanced the drug resistance of CD133-overexpressing cells in vitro and in vivo, but not that of CD133-knockdown cells, which demonstrated the contribution of CD133 to this process. In conclusion, we demonstrated that BM-MSCs increased the anti-apoptotic abilities and drug resistance of CD133-expressing cells via activation of the PI3K/Akt pathway following Bcl-2 upregulation and BAX downregulation, in which CD133 played a significant role. Targeting this route may help improve the efficacy of chemotherapy in gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-016-5319-0"xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Wang S.L."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Yu J.W."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Wu J.G."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Ji N."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Jiang B.J."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/author | "Ni X.C."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/pages | "14637-14651"xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/title | "Bone marrow-derived mesenchymal stem cells increase drug resistance in CD133-expressing gastric cancer cells by regulating the PI3K/AKT pathway."xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/27619680 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27619680 |
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