| http://purl.uniprot.org/citations/27621617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27621617 | http://www.w3.org/2000/01/rdf-schema#comment | "Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2-MDM4 complex could be a target for promising therapeutic restoration of p53 function. To this aim, a deeper understanding of the molecular mechanisms underlining the heterodimerization is needed. The kinetic and thermodynamic characterization of the MDM2-MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance. Both techniques revealed an equilibrium dissociation constant (KD ) in the micromolar range for the MDM2-MDM4 heterodimer, similar to related complexes involved in the p53 network. Furthermore, the MDM2-MDM4 complex is characterized by a relatively high free energy, through a single energy barrier, and by a lifetime in the order of tens of seconds. New insights into the MDM2-MDM4 interaction could be highly important for developing innovative anticancer drugs focused on p53 reactivation."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.org/dc/terms/identifier | "doi:10.2147/ijn.s114705"xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/author | "Moretti F."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/author | "Moscetti I."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/author | "Cannistraro S."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/author | "Bizzarri A.R."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/author | "Teveroni E."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/name | "Int J Nanomedicine"xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/pages | "4221-4229"xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/title | "MDM2-MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance."xsd:string |
| http://purl.uniprot.org/citations/27621617 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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