| http://purl.uniprot.org/citations/27626699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27626699 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphatic vessels function as transport channels for tumor cells to metastasize from the primary site into the lymph nodes. In this experiment we evaluated the effect of Sulfatase-1 (Sulf-1) on metastasis by upregulating it in murine hepatocarcinoma cell line Hca-F with high lymph node metastatic rate of >75%. The study in vitro showed that up regulation of Sulf-1 in Hca-F cells significantly reduced cell proliferation, migration and invasion (p<0.05). Also, the forced expression of Sulf-1 down regulated Mesothelin (Msln) at both the protein and mRNA levels. The experiment in vivo further showed that up-regulation of Sulf-1 with the attendant downregulation of mesothelin delayed tumor growth and decreased lymph node metastasis. In conclusion, our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis. This functional relationship between Sulf-1 and Msln could be exploited for the development of a novel liver cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.11933"xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Zhou S."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Adam M."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Ibrahim M."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Xuan W."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Xin B."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Mahmoud S."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/author | "Hago A."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/pages | "75052-75063"xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/title | "Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27626699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27626699 |