| http://purl.uniprot.org/citations/27629921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27629921 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2. However, the mechanism that IL-13Rα2 uses to mediate the effects of Chi3l1 has not been defined. Here, we demonstrate that the membrane protein, TMEM219, is a binding partner of IL-13Rα2 using yeast two-hybrid, co-immunoprecipitation, co-localization and bimolecular fluorescence complementation assays. Furthermore, fluorescence anisotropy nanodisc assays revealed a direct physical interaction between TMEM219 and IL-13Rα2-Chi3l1 complexes. Null mutations or siRNA silencing of TMEM219 or IL-13Rα2 similarly decreased Chi3l1-stimulated epithelial cell HB-EGF production and macrophage MAPK/Erk and PKB/Akt activation. Null mutations of TMEM219 or IL-13Rα2 also phenocopied one another as regards the ability of Chi3l1 to inhibit oxidant-induced apoptosis and lung injury, promote melanoma metastasis and stimulate TGF-β1. TMEM219 also contributed to the decoy function of IL-13Rα2. These studies demonstrate that TMEM219 plays a critical role in Chi3l1-induced IL-13Rα2 mediated signalling and tissue responses."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12752"xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Lee C.M."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Ma B."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Modis Y."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Lee C.G."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "He C.H."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Elias J.A."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Nour A.M."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Sharma L."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Dela Cruz C."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/author | "Nasr M.L."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/pages | "12752"xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/title | "IL-13Ralpha2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses."xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27629921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27629921 |
| http://purl.uniprot.org/citations/27629921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27629921 |
| http://purl.uniprot.org/uniprot/#_D0EFR8-mappedCitation-27629921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27629921 |
| http://purl.uniprot.org/uniprot/#_A0A024R618-mappedCitation-27629921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27629921 |