| http://purl.uniprot.org/citations/27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27638301 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone acetylation regulated by class I histone deacetylases (HDACs) plays a pivotal role in matrix-specific gene transcription and cartilage development. While we previously demonstrated that microRNA (miR)-455-3p is upregulated during chondrogenesis and can enhance early chondrogenesis, the mechanism underlying this process remains largely unclear. In this study, we characterized the effect of miR-455-3p on histone H3 acetylation and its role during cartilage development and degeneration. We observed that miR-455-3p was highly expressed in proliferating and pre-hypertrophic chondrocytes, while HDAC2 and HDAC8 were primarily expressed in hypertrophic chondrocytes. Meanwhile, miR-455-3p suppressed the activity of reporter constructs containing the 3'-untranslated regions of HDAC2/8, inhibited HDAC2/8 expression and promoted histone H3 acetylation at the collagen 2 (COL2A1) promoter in human SW1353 chondrocyte-like cells. Treatment with the HDAC inhibitor trichostatin A (TSA) resulted in increased expression of cartilage-specific genes and promoted glycosaminoglycan deposition. Moreover, TSA inhibited matrix metalloproteinase 13 (Mmp13) expression and promoted nuclear translocation of SOX9 in interleukin-1-treated primary mouse chondrocytes. Lastly, knockdown of HDAC2/3/8 increased SRY (sex-determining region Y)-box 9 (SOX9) and decreased Runt-related transcription factor 2 (RUNX2) expression. Taken together, these findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation, which raises possibilities of using miR-455-3p to influence chondrogenesis and cartilage degeneration."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2016.09.010"xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Liao W."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Sheng P."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Zhang Z.'"xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/author | "Meng F."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/pages | "2881-2891"xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/title | "MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation."xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
| http://purl.uniprot.org/citations/27638301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27638301 |
| http://purl.uniprot.org/citations/27638301 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27638301 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J008-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_B4DH31-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Q7-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_A0A7R6V290-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_B3KUJ5-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_B4DQE7-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |
| http://purl.uniprot.org/uniprot/#_C7B5P0-mappedCitation-27638301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27638301 |