| http://purl.uniprot.org/citations/27641099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27641099 | http://www.w3.org/2000/01/rdf-schema#comment | "Promoting brown adipose tissue (BAT) development is an attractive strategy for the treatment of obesity, as activated BAT dissipates energy through thermogenesis; however, the mechanisms controlling BAT formation are not fully understood. We hypothesized that as a master regulator of energy metabolism, AMP-activated protein kinase (AMPK) may play a direct role in the process and found that AMPKα1 (PRKAA1) ablation reduced Prdm16 expression and impaired BAT development. During early brown adipogenesis, the cellular levels of α-ketoglutarate (αKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter. AMPKα1 ablation reduced isocitrate dehydrogenase 2 activity and cellular αKG levels. Remarkably, postnatal AMPK activation with AICAR or metformin rescued obesity-induced suppression of brown adipogenesis and thermogenesis. In summary, AMPK is essential for the epigenetic control of BAT development through αKG, thus linking a metabolite to progenitor cell differentiation and thermogenesis."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2016.08.010"xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Du M."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Fu X."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Viollet B."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Zhu M.J."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Gang D.R."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Berim A."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Rodgers B.D."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Foretz M."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/author | "Rogers C.J."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/pages | "542-554"xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/title | "AMPK/alpha-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/27641099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27641099 |