| http://purl.uniprot.org/citations/27641493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27641493 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both in PRG-2 full knockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2-deficient thalamocortical fibers. PRG-2 electroporation in the PRG-2-/- thalamus restored the aberrant cortical innervation. We identified radixin as a PRG-2 interaction partner and showed that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2. In vivo recordings and whisker-specific behavioral tests demonstrated sensory discrimination deficits in PRG-2-/- animals. Our data show that bioactive phospholipids and PRG-2 are critical for guiding thalamic axons to their proper cortical targets."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2016.08.035"xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Kneussel M."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Ninnemann O."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Vogt J."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Yang J.W."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Fan W."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Ji H."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Huai J."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Nitsch R."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Stroh A."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Molnar Z."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Radyushkin K."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Hausrat T.J."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Maric H.M."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Stromgaard K."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Luhmann H.J."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Trimbuch T."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Hoerder-Suabedissen A."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Sabbadini R."xsd:string |
| http://purl.uniprot.org/citations/27641493 | http://purl.uniprot.org/core/author | "Endle H."xsd:string |