| http://purl.uniprot.org/citations/27643556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27643556 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocellular carcinoma (HCC) is a common, prevalent malignancy. Its poor prognosis is mainly related to high rate of diagnosis in non-curable stages, in which patients are suitable for palliative treatment. Placenta-specific 8 (PLAC8), also known as Onzin, is a small, highly conserved, cysteine-rich protein. In current study, we found that PLAC8 is prominently decreased in HCC tissues compared with adjacent tissues and patients with low level of PLAC8 suffered a poor prognosis. In addition, cellular function assays demonstrate that down-regulated PLAC8 promotes cell viability, proliferation and tumor formation both in vitro and in vivo. Furthermore, we validate that down-regulated PLAC8 enhances the activity of PI3K/Akt/GSK3β and Wnt/β-catenin signaling to promote cell proliferation. Moreover, we proved that highly expressed miR-185-5p targets PLAC8 in HCC tissues. In conclusion, our findings enlarged our knowledge about the roles of PLAC8 in HCC progression and miR-185-5p/PLAC8/β-catenin axis might be a novel pathway for HCC treatment."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2016.09.015"xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Guan J."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Zou L."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Chai J."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/author | "Du J.J."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/pages | "139-146"xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/title | "Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3beta/Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/27643556 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27643556 |
| http://purl.uniprot.org/citations/27643556 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27643556 |
| http://purl.uniprot.org/uniprot/#_D6RA24-mappedCitation-27643556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/#_Q96EJ4-mappedCitation-27643556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/#_Q9NZF1-mappedCitation-27643556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/#_X2BQ60-mappedCitation-27643556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/Q96EJ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/D6RA24 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/Q9NZF1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27643556 |
| http://purl.uniprot.org/uniprot/X2BQ60 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27643556 |