| http://purl.uniprot.org/citations/27645114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27645114 | http://www.w3.org/2000/01/rdf-schema#comment | "Latent transforming growth factor beta binding protein 4 (LTBP4) belongs to the fibrillin/LTBP family of proteins and plays an important role as a structural component of extracellular matrix (ECM) and local regulator of TGFβ signaling. We have previously reported that Ltbp4S knock out mice (Ltbp4S-/-) develop centrilobular emphysema reminiscent of late stage COPD, which could be partially rescued by inactivating the antioxidant protein Sestrin 2 (Sesn2). More recent studies showed that Sesn2 knock out mice upregulate Pdgfrβ-controlled alveolar maintenance programs that protect against cigarette smoke induced pulmonary emphysema. Based on this, we hypothesized that the emphysema of Ltbp4S-/-mice is primarily caused by defective Pdgfrβ signaling. Here we show that LTBP4 induces Pdgfrβ signaling by inhibiting the antioxidant Nrf2/Keap1 pathway in a TGFβ-dependent manner. Overall, our data identified Ltbp4 as a major player in lung remodeling and injury repair."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2016.09.006"xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Tomasovic A."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Sterner-Kock A."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Weissmann N."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Wempe F."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "von Melchner H."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Schnutgen F."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Koli K."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "De-Zolt S."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Scheibe S."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Kurrle N."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Surun D."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/author | "Serchinger M."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/pages | "109-120"xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/title | "Ltbp4 regulates Pdgfrbeta expression via TGFbeta-dependent modulation of Nrf2 transcription factor function."xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/27645114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27645114 |
| http://purl.uniprot.org/citations/27645114 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27645114 |
| http://purl.uniprot.org/uniprot/#_D3Z598-mappedCitation-27645114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645114 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-27645114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645114 |
| http://purl.uniprot.org/uniprot/#_B2RU79-mappedCitation-27645114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645114 |