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http://purl.uniprot.org/citations/27645581http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27645581http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27645581http://www.w3.org/2000/01/rdf-schema#comment"Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development. Our previous study showed that the loss of LOXL3 resulted in a severe cleft palate and spinal deformity. In this study, we investigated a possible role for LOXL3 in mouse embryonic lung development. LOXL3-deficient mice displayed reduced lung volumes and weights, diminished saccular spaces, and deformed and smaller thoracic cavities. Excess elastic fibres were detected in LOXL3-deficient lungs, which might be related to the increased LOXL4 expression. Increased transforming growth factor β1 (TGFβ1) expression might be involved in the up-regulation of LOXL4 in LOXL3-deficient lungs. We concluded that the loss of LOXL3 attenuates mouse embryonic lung development."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.org/dc/terms/identifier"doi:10.1038/srep33856"xsd:string
http://purl.uniprot.org/citations/27645581http://purl.org/dc/terms/identifier"doi:10.1038/srep33856"xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Gao J."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Gao J."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Li Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Li Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Lin Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Lin Z."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Sun X."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Sun X."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang T."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang T."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang A."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/author"Zhang A."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/name"Sci. Rep."xsd:string
http://purl.uniprot.org/citations/27645581http://purl.uniprot.org/core/name"Sci. Rep."xsd:string