| http://purl.uniprot.org/citations/27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27645996 | http://www.w3.org/2000/01/rdf-schema#comment | "αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide efficient protective anti-viral immunity, a single TCR ideally needs to cross-react with a multitude of pathogenic epitopes. However, the frequency, extent, and mechanisms of TCR cross-reactivity remain unclear, with conflicting results on anti-viral T cell cross-reactivity observed in humans. Namely, both the presence and lack of T cell cross-reactivity have been reported with HLA-A*02:01-restricted epitopes from the Epstein-Barr and influenza viruses (BMLF-1 and M158, respectively) or with the hepatitis C and influenza viruses (NS31073 and NA231, respectively). Given the high sequence similarity of these paired viral epitopes (56 and 88%, respectively), the ubiquitous nature of the three viruses, and the high frequency of the HLA-A*02:01 allele, we selected these epitopes to establish the extent of T cell cross-reactivity. We combined ex vivo and in vitro functional assays, single-cell αβTCR repertoire sequencing, and structural analysis of these four epitopes in complex with HLA-A*02:01 to determine whether they could lead to heterologous T cell cross-reactivity. Our data show that sequence similarity does not translate to structural mimicry of the paired epitopes in complexes with HLA-A*02:01, resulting in induction of distinct αβTCR repertoires. The differences in epitope architecture might be an obstacle for TCR recognition, explaining the lack of T cell cross-reactivity observed. In conclusion, sequence similarity does not necessarily result in structural mimicry, and despite the need for cross-reactivity, antigen-specific TCR repertoires can remain highly specific."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.753988"xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Valkenburg S.A."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Bharadwaj M."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Wooldridge L."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Kedzierska K."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Grant E.J."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Josephs T.M."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/author | "Hellard M."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/pages | "24335-24351"xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/title | "Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alphabetaT Cell Receptor Signatures."xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27645996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27645996 |
| http://purl.uniprot.org/citations/27645996 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-27645996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27645996 |