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| http://purl.uniprot.org/citations/27646004 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here on the relationship between ligand binding and signaling responses in the yeast pheromone response pathway, a well characterized G protein-coupled receptor system. Responses to agonist (α-factor) by cells expressing widely varying numbers of receptors depend primarily on fractional occupancy, not the absolute number of agonist-bound receptors. Furthermore, the concentration of competitive antagonist required to inhibit α-factor-dependent signaling is more than 10-fold higher than predicted based on the known ligand affinities. Thus, responses to a particular number of agonist-bound receptors can vary greatly, depending on whether there are unoccupied or antagonist-bound receptors present on the same cell surface. This behavior does not appear to be due to pre-coupling of receptors to G protein or to the Sst2p regulator of G protein signaling. The results are consistent with a signaling response that is determined by the integration of positive signals from agonist-occupied receptors and inhibitory signals from unoccupied receptors, where the inhibitory signals can be diminished by antagonist binding."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.733006"xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/author | "Dumont M.E."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/author | "Connelly S.M."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/author | "Naider F."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/author | "Sridharan R."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/pages | "24261-24279"xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/title | "Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast."xsd:string |
| http://purl.uniprot.org/citations/27646004 | http://purl.uniprot.org/core/volume | "291"xsd:string |
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