| http://purl.uniprot.org/citations/27650246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27650246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27650246 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that germline apoptosis in C. elegans increased by loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, from germ cells in adult hermaphrodite gonads. In this study, we found that somatic apoptosis was reduced in synthetic multivulva class B (synMuv B) mutants due to ectopic expression of PGL-1 and PGL-3 in the soma. In synMuv B-mutant somatic cells, CED-4 expression level was reduced due to ectopic expression of PGL-1. Furthermore, in contrast to wild type, somatic apoptosis in synMuv B mutants increased following DNA damage in a SIR-2.1-dependent manner. Intriguingly, somatic apoptosis was repressed not only in synMuv B mutants but also by ectopically expressing pgl-1 and/or pgl-3 transgenes in wild-type somatic cells. Our study demonstrates that germ-granule components, PGL-1 and PGL-3, can serve as negative regulators of apoptosis not only in the germline but also in the soma in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep33884"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep33884"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Min H."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Min H."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Kawasaki I."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Kawasaki I."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Al-Amin M."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Al-Amin M."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Shim Y.H."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/author | "Shim Y.H."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/pages | "33884"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/pages | "33884"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/title | "Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/title | "Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27650246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27650246 |
| http://purl.uniprot.org/citations/27650246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27650246 |