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http://purl.uniprot.org/citations/27660666http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27660666http://www.w3.org/2000/01/rdf-schema#comment"

Background

Colorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinomas and adenomas with high-grade dysplasia, since these are believed to harbor a particularly high risk for malignant transition and thus require resection. Promoter methylation of SEPT9 and SHOX2 has been suggested as a biomarker for various solid malignant tumors. Hence, the present study aimed to test their biomarker potential in CRC and precursor lesions.

Results

Assessment of promoter methylation of SEPT9 distinguished adenomas and CRC from controls as well as advanced from non-advanced adenomas (all p < 0.001). Correspondingly, SHOX2 methylation levels in adenomas and colorectal carcinomas were significantly higher compared to those in normal control tissues (p < 0.001). Histologic transition from adenomas to CRC was paralleled by amplification of the SEPT9 gene locus.

Conclusions

SEPT9/SHOX2 methylation assays may help to distinguish colorectal cancer and adenomas from normal and inflammatory colonic tissue, as well as advanced from non-advanced adenomas. Further studies need to validate these findings before introduction in clinical routine."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.org/dc/terms/identifier"doi:10.1186/s13148-016-0267-5"xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Dietrich D."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Kristiansen G."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Meller S."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Goltz D."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Lingohr P."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Kalff J.C."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Pantelis D."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Matthaei H."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Semaan A."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Bergheim D."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"Branchi V."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/author"van Ellen A."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/name"Clin Epigenetics"xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/pages"100"xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/title"SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas."xsd:string
http://purl.uniprot.org/citations/27660666http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/27660666http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27660666
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http://purl.uniprot.org/uniprot/#_A0A0S2Z5W9-mappedCitation-27660666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27660666
http://purl.uniprot.org/uniprot/#_A0A0S2Z5A5-mappedCitation-27660666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27660666
http://purl.uniprot.org/uniprot/#_A2VCQ5-mappedCitation-27660666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27660666
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