| http://purl.uniprot.org/citations/27663963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27663963 | http://www.w3.org/2000/01/rdf-schema#comment | "M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid tissues. These unique phagocytic epithelial cells enable the mucosal immune system to sample antigens within the lumen of the intestine. The differentiation of M cells from uncommitted precursors in the FAE is dependent on the production of receptor activator of nuclear factor-κB ligand (RANKL) by subepithelial stromal cells. The ligation of a variety of cell surface receptors activates the nuclear factor-κB (NF-κB) family of transcription factors which in-turn induce the transcription of multiple target genes. RANKL-stimulation can stimulate the nuclear translocation of the NF-κB subunit c-Rel. We therefore used c-Rel-deficient mice to determine whether the differentiation and functional maturation of M cells in the Peyer's patches was dependent on c-Rel. Our data show that c-Rel-deficiency does not influence the expression of RANKL or RANK in Peyer's patches, or the induction of M-cell differentiation in the FAE. RANKL-stimulation in the differentiating M cells induces the expression of SpiB which is essential for their subsequent maturation. However, SpiB expression in the FAE was also unaffected in the absence of c-Rel. As a consequence, the functional maturation of M cells was not impaired in the Peyer's patches of c-Rel-deficient mice. Although our data showed that the specific expression of CCL20 and ubiquitin D in the FAE was not impeded in the absence of c-Rel, the expression of ubiquitin D was dramatically reduced in the B cell-follicles of c-Rel-deficient mice. Coincident with this, we also observed that the status of follicular dendritic cells in the B cell-follicles was dramatically reduced in Peyer's patches from c-Rel-deficient mice. Taken together, our data show that c-Rel is dispensable for the RANKL-mediated differentiation and functional maturation of M cells."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2016.09.008"xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/author | "Kobayashi A."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/author | "Sehgal A."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/author | "Mabbott N.A."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/author | "Donaldson D.S."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/pages | "316-326"xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/title | "c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium."xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://purl.uniprot.org/core/volume | "222"xsd:string |
| http://purl.uniprot.org/citations/27663963 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27663963 |
| http://purl.uniprot.org/citations/27663963 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27663963 |
| http://purl.uniprot.org/uniprot/#_P15307-mappedCitation-27663963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27663963 |
| http://purl.uniprot.org/uniprot/#_A4QPD3-mappedCitation-27663963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27663963 |
| http://purl.uniprot.org/uniprot/A4QPD3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27663963 |
| http://purl.uniprot.org/uniprot/P15307 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27663963 |