| http://purl.uniprot.org/citations/27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27664281 | http://www.w3.org/2000/01/rdf-schema#comment | "Diverse signals received by CD8+ T cells are integrated to achieve the required magnitude of cell expansion and the appropriate balance of effector/memory CD8+ T cell generation. Notably, the strength and nature of TCR signaling influence the differentiation and functional capacity of effector and memory CD8+ T cells. Dok-1 and Dok-2, the two members of the Dok family expressed in T cells, negatively regulate TCR signaling in vitro. However, the role of Dok proteins in modulating T cell function in vivo has not yet studied. We studied the function of Dok-1 and Dok-2 proteins in the regulation of the CD8+ T cell response to vaccinia virus infection. Comparison of responses to vaccinia virus expressing OVA peptide SIINFEKL by wild-type and Dok-1/2-/- CD8+ OT-I cells showed that the absence of Dok-1 and Dok-2 slightly reduced the magnitude of virus-specific effector CD8+ T cell expansion. This was not due to reduced proliferation or enhanced apoptosis of effector CD8+ T cells. Dok-1/2-deficient effector CD8+ T cells showed increased cell surface TCR expression following virus infection in vivo and increased expression of granzyme B and TNF upon stimulation with peptide Ag ex vivo. Finally, Dok-1/2-deficient effector CD8+ T had a severe defect in survival that resulted in impaired generation of memory CD8+ T cells. These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8+ T cells and promotes memory formation."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1600385"xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Klinck R."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Lamarre A."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Charpentier T."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Tarrab E."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Duplay P."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Yousefi M."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Stager S."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Labrecque N."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Daudelin J.F."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/author | "Laroche-Lefebvre C."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/pages | "3618-3627"xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/title | "Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells."xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/27664281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27664281 |
| http://purl.uniprot.org/citations/27664281 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27664281 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW01-mappedCitation-27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27664281 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW29-mappedCitation-27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27664281 |
| http://purl.uniprot.org/uniprot/#_P97465-mappedCitation-27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27664281 |
| http://purl.uniprot.org/uniprot/#_Q3U208-mappedCitation-27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27664281 |
| http://purl.uniprot.org/uniprot/#_Q3TX09-mappedCitation-27664281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27664281 |