| http://purl.uniprot.org/citations/27666591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27666591 | http://www.w3.org/2000/01/rdf-schema#comment | "CENP-A is a centromere-specific histone 3 variant essential for centromere specification. CENP-A partially replaces canonical histone H3 at the centromeres. How the particular CENP-A/H3 ratio at centromeres is precisely maintained is unknown. It also remains unclear how CENP-A is excluded from non-centromeric chromatin. Here, we identify Ccp1, an uncharacterized NAP family protein in fission yeast that antagonizes CENP-A loading at both centromeric and non-centromeric regions. Like the CENP-A loading factor HJURP, Ccp1 interacts with CENP-A and is recruited to centromeres at the end of mitosis in a Mis16-dependent manner. These data indicate that factors with opposing CENP-A loading activities are recruited to centromeres. Furthermore, Ccp1 also cooperates with H2A.Z to evict CENP-A assembled in euchromatin. Structural analyses indicate that Ccp1 forms a homodimer that is required for its anti-CENP-A loading activity. Our study establishes mechanisms for maintenance of CENP-A homeostasis at centromeres and the prevention of ectopic assembly of centromeres."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.08.022"xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Gonzalez M."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Su M."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Dong Q."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/author | "Yin F.X."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/pages | "79-91"xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/title | "Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading."xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/27666591 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27666591 |
| http://purl.uniprot.org/citations/27666591 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27666591 |
| http://purl.uniprot.org/uniprot/P48003#attribution-7495CB0D58DDEFD806DA35AA01E202C9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27666591 |
| http://purl.uniprot.org/uniprot/Q9HGN2#attribution-C540FD247B2970314E1DC2CFA62C6D89 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27666591 |