| http://purl.uniprot.org/citations/27667124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27667124 | http://www.w3.org/2000/01/rdf-schema#comment | "To establish an effective cancer immunotherapy, it is crucial that cancer cells present a cancer-specific antigen in a hypoxic area, a hallmark of the tumor microenvironment. Here, we show the impact of hypoxia on MHC class I antigen presentation in vitro and in vivo in murine tumors. Activation of antigen-specific CTLs by tumor cells that had been pre-incubated under a condition of hypoxia was enhanced compared with that by tumor cells pre-incubated under a condition of normoxia. Cell surface expression of MHC class I-peptide complex on the tumor cells was increased under a condition of hypoxia, thereby leading to higher susceptibility to specific CTLs. We show that the hypoxia-inducible ER-resident oxidase ERO1-α plays an important role in the hypoxia-induced augmentation of MHC class I-peptide complex expression. ERO1-α facilitated oxidative folding of MHC class I heavy chains, thereby resulting in the augmentation of cell surface expression of MHC class I-peptide complex under hypoxic conditions. These results suggest that since the expression of MHC class I-peptide complex is augmented in a hypoxic tumor microenvironment, strategies for inhibiting the function of regulatory T cells and myeloid-derived suppressor cells and/or immunotherapy with immune checkpoint inhibitors are promising for improving cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201646525"xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Hirata K."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Kajiwara T."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Okuya K."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Torigoe T."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Takaya A."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Tsukahara T."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Kochin V."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Hirohashi Y."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Kukita K."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Kanaseki T."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/author | "Kutomi G."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/pages | "2842-2851"xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/title | "Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-alpha-mediated oxidative folding in murine tumor cells."xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/27667124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27667124 |
| http://purl.uniprot.org/citations/27667124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27667124 |