| http://purl.uniprot.org/citations/27669165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27669165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27669165 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin defining the functions of such poorly characterized proteins, we used mass spectrometry to map the proteomes, lipidomes, and metabolomes of 174 yeast strains, each lacking a single gene related to mitochondrial biology. 144 of these genes have human homologs, 60 of which are associated with disease and 39 of which are uncharacterized. We present a multi-omic data analysis and visualization tool that we use to find covariance networks that can predict molecular functions, correlations between profiles of related gene deletions, gene-specific perturbations that reflect protein functions, and a global respiration deficiency response. Using this multi-omic approach, we link seven proteins including Hfd1p and its human homolog ALDH3A1 to mitochondrial coenzyme Q (CoQ) biosynthesis, an essential pathway disrupted in many human diseases. This Resource should provide molecular insights into mitochondrial protein functions."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.org/dc/terms/identifier | "doi:10.1038/nbt.3683"xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.org/dc/terms/identifier | "doi:10.1038/nbt.3683"xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Coon J.J."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Coon J.J."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Pagliarini D.J."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Pagliarini D.J."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Jochem A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Jochem A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Stefely J.A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Stefely J.A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Ulbrich A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Ulbrich A."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Veling M.T."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Veling M.T."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Westphall M.S."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Westphall M.S."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Richards A.L."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Richards A.L."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Hebert A.S."xsd:string |
| http://purl.uniprot.org/citations/27669165 | http://purl.uniprot.org/core/author | "Hebert A.S."xsd:string |