| http://purl.uniprot.org/citations/27671655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27671655 | http://www.w3.org/2000/01/rdf-schema#comment | "The tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca2+ channels and via RIM with other components of the release machinery. Although human RIM-BPs have been implicated in autism spectrum disorders, little is known about the role of mammalian RIM-BPs in synaptic transmission. We investigated RIM-BP2-deficient murine hippocampal neurons in cultures and slices. Short-term facilitation is significantly enhanced in both model systems. Detailed analysis in culture revealed a reduction in initial release probability, which presumably underlies the increased short-term facilitation. Superresolution microscopy revealed an impairment in CaV2.1 clustering at AZs, which likely alters Ca2+ nanodomains at release sites and thereby affects release probability. Additional deletion of RIM-BP1 does not exacerbate the phenotype, indicating that RIM-BP2 is the dominating RIM-BP isoform at these synapses."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1605256113"xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Eickholt B.J."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Maglione M."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Haucke V."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Schmitz D."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Brockmann M.M."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Pangalos M."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Rost B.R."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Rosenmund T."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Reddy-Alla S."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Walter A.M."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Trimbuch T."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Stumpf A."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Vardar G."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Grauel M.K."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/author | "Willmes C.G."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/pages | "11615-11620"xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/title | "RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses."xsd:string |
| http://purl.uniprot.org/citations/27671655 | http://purl.uniprot.org/core/volume | "113"xsd:string |