Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/27671905http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27671905http://www.w3.org/2000/01/rdf-schema#comment"

Background

The proteasome system is involved in several disorders. The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) -8 C/G, associated with diabetes, myocardial infarction and coronary artery disease.

Methods

We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for -8 C/G SNP by polymerase chain reaction and restriction analysis.

Results

We observed lower frequency of CG + GG genotypes in patients than in controls (20 vs. 42 %, p = 0.0038). The odds ratio of 0.34 (95 % CI 0.26-0.45) suggests association of CG + GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54 % of patients. There was a significant association of CG + GG genotype with LVH, with over 75 % of CG + GG in patients with LVH. This effect was independent from other common causes of LVH-age (OR 1.12, p = 0.643) and hypertension (OR 1.72, p = 0.422).

Conclusion

We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG + GG genotypes are independently related to LVH in ESKD patients."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.org/dc/terms/identifier"doi:10.1007/s11255-016-1420-y"xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/author"Stec A."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/author"Buraczynska M."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/author"Ksiazek A."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/author"Filipczak A."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/name"Int Urol Nephrol"xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/pages"2083-2087"xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/title"Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease."xsd:string
http://purl.uniprot.org/citations/27671905http://purl.uniprot.org/core/volume"48"xsd:string
http://purl.uniprot.org/citations/27671905http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27671905
http://purl.uniprot.org/citations/27671905http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27671905
http://purl.uniprot.org/uniprot/#_A0A140VK44-mappedCitation-27671905http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27671905
http://purl.uniprot.org/uniprot/#_P60900-mappedCitation-27671905http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27671905
http://purl.uniprot.org/uniprot/#_Q9BZ93-mappedCitation-27671905http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27671905
http://purl.uniprot.org/uniprot/Q9BZ93http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27671905
http://purl.uniprot.org/uniprot/A0A140VK44http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27671905
http://purl.uniprot.org/uniprot/P60900http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27671905