| http://purl.uniprot.org/citations/27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27683122 | http://www.w3.org/2000/01/rdf-schema#comment | "A dynamic phenotypic change contributes to the metastatic progression and drug resistance in malignant melanoma. Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metastatic melanoma, the cells are composed of Met-low and Met-high populations. Met-low populations have stem-like gene expression profiles, are resistant to chemotherapeutic agents, and have shown abundant angiogenesis and rapid tumor growth in subcutaneous inoculation. Met-high populations have a differentiated phenotype, are relatively resistant to B-RAF inhibitor, and are highly metastatic to the lungs. Met plays a definitive role in lung metastasis because the lung metastasis of Met-high cells requires Met, and treatment of mice with the Met-containing exosomes from Met-high cells facilitates lung metastasis by Met-low cells. Clonal cell fate analysis showed the hierarchical phenotypical changes from Met-low to Met-high populations. Met-low cells either showed self-renewal or changed into Met-high cells, whereas Met-high cells remained Met-high. Clonal transition from Met-low to Met-high cells accompanied changes in the gene expression profile, in tumor growth, and in metastasis that were similar to those in Met-high cells. These findings indicate that malignant melanoma has the ability to undergo phenotypic change by a cell-intrinsic/autonomous mechanism that can be characterized by Met expression."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.12221"xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Sakai K."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Sato H."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Imamura R."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Nishiuchi T."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/author | "Adachi E."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/pages | "70779-70793"xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/title | "Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma."xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27683122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27683122 |
| http://purl.uniprot.org/citations/27683122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27683122 |
| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A935-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A936-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A937-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A938-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A939-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A940-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A941-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |
| http://purl.uniprot.org/uniprot/#_B5A942-mappedCitation-27683122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27683122 |