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http://purl.uniprot.org/citations/27687004http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27687004http://www.w3.org/2000/01/rdf-schema#comment"Plasmablastic lymphoma is an uncommon aggressive non-Hodgkin B-cell lymphoma type defined as a high-grade large B-cell neoplasm with plasma cell phenotype. Genetic alterations in MYC have been found in a proportion (~60%) of plasmablastic lymphoma cases and lead to MYC-protein overexpression. Here, we performed a genetic and expression profile of 36 plasmablastic lymphoma cases and demonstrate that MYC overexpression is not restricted to MYC-translocated (46%) or MYC-amplified cases (11%). Furthermore, we demonstrate that recurrent somatic mutations in PRDM1 are found in 50% of plasmablastic lymphoma cases (8 of 16 cases evaluated). These mutations target critical functional domains (PR motif, proline rich domain, acidic region, and DNA-binding Zn-finger domain) involved in the regulation of different targets such as MYC. Furthermore, these mutations are found frequently in association with MYC translocations (5 out of 9, 56% of cases with MYC translocations were PRDM1-mutated), but not restricted to those cases, and lead to expression of an impaired PRDM1/Blimp1α protein. Our data suggest that PRDM1 mutations in plasmablastic lymphoma do not impair terminal B-cell differentiation, but contribute to the oncogenicity of MYC, usually disregulated by MYC translocation or MYC amplification. In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1α owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.org/dc/terms/identifier"doi:10.1038/modpathol.2016.162"xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Linares E."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Batlle A."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Almaraz C."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Montes-Moreno S."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Piris M.A."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Rodriguez-Pinilla M."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Cereceda-Company L."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Martinez-Magunacelaya N."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Ranchal T."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Revert-Arce J.B."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Villambrosia S.G."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/author"Zecchini-Barrese T."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/name"Mod Pathol"xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/pages"85-94"xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/title"Plasmablastic lymphoma phenotype is determined by genetic alterations in MYC and PRDM1."xsd:string
http://purl.uniprot.org/citations/27687004http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/27687004http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27687004
http://purl.uniprot.org/citations/27687004http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27687004
http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-27687004http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27687004
http://purl.uniprot.org/uniprot/#_A1YZ20-mappedCitation-27687004http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27687004
http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-27687004http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27687004