| http://purl.uniprot.org/citations/2769267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2769267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2769267 | http://www.w3.org/2000/01/rdf-schema#comment | "This report describes the purification and characterization from rat brain of triakontatetraneuropeptide (TTN, DBI 17-50), a major biologically active processing product of diazepam binding inhibitor (DBI). Brain TTN was purified by immunoaffinity chromatography with polyclonal octadecaneuropeptide, DBI 33-50) antibodies coupled to CNBr-Sepharose 4B followed by two reverse-phase HPLC steps. The amino acid sequence of the purified peptide is: Thr-Gln-Pro-Thr-Asp-Glu-Glu-Met-Leu-Phe-Ile-Tyr-Ser-His-Phe-Lys-Gln-Ala-Thr-Val - Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys. Synthetic TTN injected intracerebroventricularly into rats induces a proconflict activity (IC50 0.8 nmol/rat) that is prevented by the specific "peripheral" benzodiazepine (BZ) receptor antagonist isoquinoline carboxamide, PK 11195, but not by the "central" BZ receptor antagonist imidazobenzodiazepine, flumazenil. TTN displaces [3H]Ro 5-4864 from synaptic membranes of olfactory bulb with a Ki of approximately 5 microM. TTN also enhances picrotoxinin inhibition of gamma-aminobutyric acid (GABA)-stimulated [3H]flunitrazepam binding. These data suggest that TTN, a natural DBI processing product acting at "Ro 5-4864 preferring" BZ binding site subtypes, might function as a putative neuromodulator of specific GABAA receptor-mediated effects."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.1989.tb07425.x"xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.1989.tb07425.x"xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Costa E."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Costa E."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Guidotti A."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Guidotti A."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Berkovich A."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Berkovich A."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Slobodyansky E."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Slobodyansky E."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Wambebe C."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/author | "Wambebe C."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/pages | "1276-1284"xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/pages | "1276-1284"xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/title | "Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/title | "Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site."xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/2769267 | http://purl.uniprot.org/core/volume | "53"xsd:string |