| http://purl.uniprot.org/citations/27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27692835 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatoma-derived growth factor (HDGF) is a heparin-binding growth factor, which has previously been shown to be expressed in a variety of cancers. HDGF overexpression has also previously been correlated with a poor prognosis in several cancers. The significance of HDGF in prostate cancer, however, has not been investigated. Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells. Forced overexpression enhanced cell viability of RWPE-1 cells, whereas HDGF knockdown reduced cell proliferation in human prostate cancer cells. We also show that HDGF may serve as a survival-related protein as ectopic overexpression of HDGF in RWPE cells up-regulated the expression of antiapoptosis proteins cyclin E and BCL-2, whereas simultaneously down-regulating proapoptotic protein BAX. Western blot analysis also showed that HDGF overexpression modulated the activity of phospho-AKT as well as NF-kB, and these results correlated with in vitro migration and invasion assays. We next assessed the therapeutic potential of HDGF inhibition with a HDGF monoclonal antibody and vitamin k2, showing reduced cell proliferation as well as inhibition of NF-kB expression in HDGF overexpressed RWPE cells treated with a HDGF monoclonal antibody and vitamin K2. Collectively, our results suggest that HDGF is a relevant protein in prostate oncogenesis and may serve as a potential therapeutic target in prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.urolonc.2016.05.027"xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Zheng G."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Shetty A."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Kajdacsy-Balla A."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Dasari S."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Munirathinam G."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Bosland M.C."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/author | "Gheewala T."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/name | "Urol Oncol"xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/pages | "483.e1-483.e8"xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/title | "Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2."xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/27692835 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27692835 |
| http://purl.uniprot.org/citations/27692835 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27692835 |
| http://purl.uniprot.org/uniprot/#_A0A384NPW1-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |
| http://purl.uniprot.org/uniprot/#_B2RDE8-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |
| http://purl.uniprot.org/uniprot/#_B7Z525-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |
| http://purl.uniprot.org/uniprot/#_A8K8G0-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |
| http://purl.uniprot.org/uniprot/#_B7Z958-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |
| http://purl.uniprot.org/uniprot/#_P51858-mappedCitation-27692835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27692835 |