| http://purl.uniprot.org/citations/27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27696330 | http://www.w3.org/2000/01/rdf-schema#comment | "The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13238-016-0320-3"xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/author | "Gao G."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/author | "Gao P."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/author | "Xia P."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/name | "Protein Cell"xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/pages | "777-791"xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/title | "DNA sensor cGAS-mediated immune recognition."xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27696330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27696330 |
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| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |
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| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |
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| http://purl.uniprot.org/uniprot/#_A0A494C0W5-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |
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| http://purl.uniprot.org/uniprot/#_A0A3S9KRB7-mappedCitation-27696330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27696330 |