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http://purl.uniprot.org/citations/27699510http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27699510http://www.w3.org/2000/01/rdf-schema#comment"

Background

Hepatocellular carcinoma is a major type of liver cancer with poor prognosis.

Aim

The aim of the study was to determine the prognostic significance of plasma interleukin-35 level in hepatocellular carcinoma.

Methods

A total of 153 hepatocellular carcinoma patients and 153 healthy controls were enrolled. Blood samples were obtained at admission. Plasma interleukin-35 level was analyzed by enzyme-linked immunosorbent assay. Distribution of T cell subset and expression of Fas/FasL protein were detected by flow cytometry. The patients were followed up for 2 years. Poor prognosis was defined as death of hepatocellular carcinoma.

Results

The plasma levels of interleukin-35 were significantly higher in the patients than the controls (25.1 ± 13.1, 9.3 ± 6.3 pg/mL, P < 0.001). After adjusted for multiple confounding factors, the multivariate logistic regression analyses reported that high level of interleukin-35 (≥25.0 pg/mL) was associated with the poor prognosis in the patients (OR 6.63, 95 % CI 3.27-13.47). Compared with the patients with low level of interleukin-35 (<25.0 pg/mL), the patients with high level of interleukin-35 showed higher frequencies of CD4+CD25+FoxP3+ and CD3+Foxp3+ regulatory T cells (P < 0.001 and P < 0.001) and also showed higher apoptosis levels of CD8+ T cells (P < 0.001).

Conclusion

Circulating interleukin-35 concentration might be an independent prognostic indicator in hepatocellular carcinoma. Such prognostic significance could be partly involved in the activation of regulatory T cell and the apoptosis of CD8+ T cell."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.org/dc/terms/identifier"doi:10.1007/s10620-016-4270-7"xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/author"Chen L."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/author"Song Y."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/author"Qiu X."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/name"Dig Dis Sci"xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/pages"3513-3521"xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/title"Plasma Level of Interleukin-35 as an Independent Prognostic Indicator in Hepatocellular Carcinoma."xsd:string
http://purl.uniprot.org/citations/27699510http://purl.uniprot.org/core/volume"61"xsd:string
http://purl.uniprot.org/citations/27699510http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27699510
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