| http://purl.uniprot.org/citations/27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27705802 | http://www.w3.org/2000/01/rdf-schema#comment | "Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders. Despite the strength of data linking PRODH and L-proline to neuropsychiatric diseases, targets of disease-relevant concentrations of L-proline have not been convincingly described. Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets. However, at disease-relevant concentrations, GABA-mimesis is limited to competitive blockade of glutamate decarboxylase leading to reduced GABA production. Significantly, deficits in GABA-ergic transmission are reversed by enhancing net GABA production with the clinically relevant compound vigabatrin. These findings indicate that accumulation of a neuroactive metabolite can lead to molecular and synaptic dysfunction and help to understand mechanisms underlying neuropsychiatric disease."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.09.029"xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/author | "Park A.J."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/author | "Gogos J.A."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/author | "Crabtree G.W."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/author | "Gordon J.A."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/pages | "570-582"xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/title | "Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade."xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27705802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27705802 |
| http://purl.uniprot.org/citations/27705802 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27705802 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1T9-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_A0A338P738-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_A0A481ZHW6-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_A0A481ZII7-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_F6YFQ5-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_E9PUR5-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_F6XMC0-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_F6PYI8-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_O43272-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_Q8C3G7-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |
| http://purl.uniprot.org/uniprot/#_Q9WU79-mappedCitation-27705802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27705802 |