| http://purl.uniprot.org/citations/27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27708106 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals adapt their growth rate and body size to available nutrients by a general modulation of insulin-insulin-like growth factor signaling. In Drosophila, dietary amino acids promote the release in the hemolymph of brain insulin-like peptides (Dilps), which in turn activate systemic organ growth. Dilp secretion by insulin-producing cells involves a relay through unknown cytokines produced by fat cells. Here, we identify Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling. We further show, using genetic and ex vivo organ culture experiments, that the Mth ligand Stunted (Sun) is a circulating insulinotropic peptide produced by fat cells. Therefore, Sun and Mth define a new cross-organ circuitry that modulates physiological insulin levels in response to nutrients."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaf8430"xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "McNeill H."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Leopold P."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Tsatskis Y."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Delanoue R."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Agrawal N."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Mauri A."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/author | "Meschi E."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/pages | "1553-1556"xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/title | "Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor."xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://purl.uniprot.org/core/volume | "353"xsd:string |
| http://purl.uniprot.org/citations/27708106 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27708106 |
| http://purl.uniprot.org/citations/27708106 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27708106 |
| http://purl.uniprot.org/uniprot/#_E1JHX3-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_O97148-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_M9PD17-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_Q7K0T0-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_Q8IH74-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_Q5U183-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_Q9VCC9-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |
| http://purl.uniprot.org/uniprot/#_Q9VW83-mappedCitation-27708106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27708106 |