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http://purl.uniprot.org/citations/2771945http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/2771945http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/2771945http://www.w3.org/2000/01/rdf-schema#comment"The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.org/dc/terms/identifier"doi:10.1073/pnas.86.17.6587"xsd:string
http://purl.uniprot.org/citations/2771945http://purl.org/dc/terms/identifier"doi:10.1073/pnas.86.17.6587"xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/author"van Roey P."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/author"van Roey P."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/author"Beerman T.A."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/author"Beerman T.A."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/date"1989"xsd:gYear
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/date"1989"xsd:gYear
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/pages"6587-6591"xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/pages"6587-6591"xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/title"Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/title"Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity."xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/volume"86"xsd:string
http://purl.uniprot.org/citations/2771945http://purl.uniprot.org/core/volume"86"xsd:string
http://purl.uniprot.org/citations/2771945http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/2771945
http://purl.uniprot.org/citations/2771945http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/2771945
http://purl.uniprot.org/citations/2771945http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/2771945
http://purl.uniprot.org/citations/2771945http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/2771945
http://purl.uniprot.org/uniprot/P01549http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/2771945
http://purl.uniprot.org/uniprot/#_P01549-citation-2771945http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/2771945