| http://purl.uniprot.org/citations/27721403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27721403 | http://www.w3.org/2000/01/rdf-schema#comment | "The accumulation of myeloid-derived suppressor cells (MDSCs) has been observed in solid tumors and is correlated with tumor progression; however, the underlying mechanism is still poorly understood. In this study, we identified a mechanism by which tumor cells induce MDSC accumulation and expansion in the bladder cancer (BC) microenvironment via CXCL2/MIF-CXCR2 signaling. Elevated expression of CXCL2 and MIF and an increased number of CD33+ MDSCs were detected in BC tissues, and these increases were significantly associated with advanced disease stage and poor patient prognosis (P<0.01). A positive association was observed between CXCL2 or MIF expression and the number of tumor-infiltrating CD33+ MDSCs (P<0.01). Subsequently, we demonstrated that CD45+CD33+CD11b+HLA-DR- MDSCs from fresh BC tissues displayed high levels of suppressive molecules, including Arg1, iNOS, ROS, PDL-1 and P-STAT3, and stronger suppression of T-cell proliferation. Interestingly, these CD45+CD33+CD11b+HLA-DR- MDSCs exhibited increased CXCR2 expression compared with that in peripheral blood from BC patients or healthy controls (P<0.05). Chemotaxis assay revealed that bladder cancer cell line J82 induced MDSC migration via CXCL2/MIF-CXCR2 signaling in vitro. Mechanistic studies demonstrated that J82-induced MDSC trafficking and CXCR2 expression were associated with increased phosphorylation of p38, ERK and p65. Conversely, inhibition of the phosphorylation of p38, ERK or p65 decreased J82-induced MDSC trafficking and CXCR2 expression. CXCL2/MIF-stimulated activation of the mitogen-activated protein kinase and nuclear factor kappa B pathways in MDSCs was MyD88 dependent. Overall, our results identify the CXCL2/MIF-CXCR2 axis as an important mediator in MDSC recruitment and as predictors and potential therapeutic targets in BC patients."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2016.367"xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Li M.X."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Zhang X.S."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Wang R.F."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Zhou F.J."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Peng J.Y."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Huang W.R."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Ye Y.L."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Ye S.B."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Cai T.T."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/author | "Duan T.H."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/pages | "2095-2104"xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/title | "CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer."xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/27721403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27721403 |
| http://purl.uniprot.org/citations/27721403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27721403 |
| http://purl.uniprot.org/uniprot/#_P14174-mappedCitation-27721403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27721403 |