| http://purl.uniprot.org/citations/27723720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27723720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27723720 | http://www.w3.org/2000/01/rdf-schema#comment | "The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient cells accumulate double-strand breaks, sister chromatid exchanges, and other hallmarks of genome instability. They are also hypersensitive to replication stress and have increased frequencies of replication fork collapse. ETAA1 contains two RPA-interaction motifs that localize ETAA1 to stalled replication forks. It also interacts with several DNA damage response proteins including the BLM/TOP3α/RMI1/RMI2 and ATR/ATRIP complexes. It binds ATR/ATRIP directly using a motif with sequence similarity to the TOPBP1 ATR-activation domain; and like TOPBP1, ETAA1 acts as a direct ATR activator. ETAA1 functions in parallel to the TOPBP1/RAD9/HUS1/RAD1 pathway to regulate ATR and maintain genome stability. Thus, vertebrate cells contain at least two ATR-activating proteins."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3415"xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3415"xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Cortez D."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Cortez D."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Chazin W.J."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Chazin W.J."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Bass T.E."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Bass T.E."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Carroll C."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Carroll C."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Dungrawala H."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Dungrawala H."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Feldkamp M.D."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Feldkamp M.D."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Glick G.G."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Glick G.G."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Kavanaugh G."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Kavanaugh G."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Luzwick J.W."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Luzwick J.W."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Putney R."xsd:string |
| http://purl.uniprot.org/citations/27723720 | http://purl.uniprot.org/core/author | "Putney R."xsd:string |