| http://purl.uniprot.org/citations/27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27733582 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone and cartilage destruction is one of the key manifestations of rheumatoid arthritis (RA). Although the role of T helper (Th)17 cells in these processes is clear, the role of IL-21-producing cells T cells has been neglected. We sought to investigate the role of IL-21 in RA by focusing on the functional characteristics of the main producers of this cytokine, synovial CD4+IL-21+ T cells. We show that the frequency of both synovial fluid (SF) CD4+IL-21+ or CD4+IL-21+TNF+ T cells in patients with RA was significantly higher compared with patients with psoriatic arthritis (PsA). The frequency of peripheral blood (PB) IL-21+CD4+ T cells in patients with RA positively correlated with disease activity score 28 (DAS28), serum anticyclic citrullinated peptide (anti-CCP) antibodies and IgM-rheumatoid factor (IgM-RF). IL-21 levels in RA SF were associated with matrix metalloproteinase (MMP)-1 and MMP-3. Related to this, IL-21 induced significantly the secretion of MMP-1 and MMP-3 in RA synovial biopsies. Sorted SF CD4+IL-21+ T cells significantly induced the release of MMP-1 and MMP-3 by fibroblast-like synoviocytes (FLS) compared with medium or CD4+IL-21- T cells in a coculture system. Neutralization of both IL-21 and TNF resulted in significantly less production of MMP by FLS. The results of this study indicate a new role for synovial CD4+IL-21+TNF+ T cells in promoting synovial inflammation/joint destruction in patients with RA. Importantly, IL-21 blockade in combination with anti-TNF might be an effective therapy in patients with RA by inhibiting MMP-induced inflammation/joint destruction."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.5a0516-217rr"xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Screaton G.R."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Tak P.P."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Vieira P.L."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Aarrass S."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Lebre M.C."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Helder B."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Newsom-Davis T."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/author | "Tang M.W."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/pages | "775-783"xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/title | "Synovial IL-21/TNF-producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes."xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/27733582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27733582 |
| http://purl.uniprot.org/citations/27733582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27733582 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |
| http://purl.uniprot.org/uniprot/#_A0A0U3J4I2-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |
| http://purl.uniprot.org/uniprot/#_A0A224B028-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |
| http://purl.uniprot.org/uniprot/#_A5GZ69-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |
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| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-27733582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27733582 |