| http://purl.uniprot.org/citations/27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27738016 | http://www.w3.org/2000/01/rdf-schema#comment | "Quiescent cells play a predominant role in most organisms. Here we identify RNA interference (RNAi) as a major requirement for quiescence (G0 phase of the cell cycle) in Schizosaccharomyces pombe RNAi mutants lose viability at G0 entry and are unable to maintain long-term quiescence. We identified suppressors of G0 defects in cells lacking Dicer (dcr1Δ), which mapped to genes involved in chromosome segregation, RNA polymerase-associated factors, and heterochromatin formation. We propose a model in which RNAi promotes the release of RNA polymerase in cycling and quiescent cells: (i) RNA polymerase II release mediates heterochromatin formation at centromeres, allowing proper chromosome segregation during mitotic growth and G0 entry, and (ii) RNA polymerase I release prevents heterochromatin formation at ribosomal DNA during quiescence maintenance. Our model may account for the codependency of RNAi and histone H3 lysine 9 methylation throughout eukaryotic evolution."xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aah5651"xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/author | "Martienssen R.A."xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/author | "Roche B."xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/author | "Arcangioli B."xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/pages | "aah5651"xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/title | "RNA interference is essential for cellular quiescence."xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://purl.uniprot.org/core/volume | "354"xsd:string |
| http://purl.uniprot.org/citations/27738016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27738016 |
| http://purl.uniprot.org/citations/27738016 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27738016 |
| http://purl.uniprot.org/uniprot/O74957#attribution-81C65E9F3A2AB10D99569B2F33DC225C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/Q09884#attribution-81C65E9F3A2AB10D99569B2F33DC225C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/O14227#attribution-81C65E9F3A2AB10D99569B2F33DC225C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O42934-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_Q10325-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_Q10426-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_Q10198-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O60016-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O14227-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O14343-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O74560-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |
| http://purl.uniprot.org/uniprot/#_O74957-mappedCitation-27738016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27738016 |