| http://purl.uniprot.org/citations/27744593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27744593 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadmium (Cd) has known to produce many adverse effects on organs including placenta. Many essential transporters are involved in Cd transport pathways such as DMT-1, ZIP as well as L-VDCC. Fourteen pregnant women participated and were divided into two groups: high and low Cd-exposed (H-Cd, L-Cd) groups on the basis of their residential areas, Cd concentrations in the blood (B-Cd), urine (U-Cd), and placenta (P-Cd). The results showed that the B-Cd and U-Cd were significantly increased in H-Cd group (p < 0.05). Interestingly, the P-Cd in H-Cd group was elevated (p < 0.05) and positively related to their B-Cd and U-Cd values (p < 0.05). However, the mean cord blood Cd (C-Cd) concentration in H-Cd group was not significantly increased about 2.5-fold when comparing to L-Cd group. To determine the Cd accumulation in placental tissues, metallothionein-1A (MT-1A) and metallothionein-2A (MT-2A) expressions were used as biomarkers. The results revealed that mean MT-1A and MT-2A mRNAs and MT-1/2 proteins were up-regulated in H-Cd group (p < 0.05). In addition, the Ca channel alpha 1C (CACNA1C) mRNA and protein expressions were noticeably elevated in H-Cd group (p < 0.05). From these findings, we suggested that CACNA1C might be implicated in Cd transport in human placenta."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11356-016-7841-4"xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Hipkaeo W."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Sakulsak N."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Cheunchoojit S."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Phuapittayalert L."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Saenganantakarn P."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/author | "Supanpaiboon W."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/name | "Environ Sci Pollut Res Int"xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/pages | "24592-24600"xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/title | "Increasing CACNA1C expression in placenta containing high Cd level: an implication of Cd toxicity."xsd:string |
| http://purl.uniprot.org/citations/27744593 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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