| http://purl.uniprot.org/citations/27746021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27746021 | http://www.w3.org/2000/01/rdf-schema#comment | "In advanced stages of cancers, TGF-β promotes tumor progression in conjunction with inputs from receptor tyrosine kinase pathways. However, mechanisms that underpin the signaling cooperation and convert TGF-β from a potent growth inhibitor to a tumor promoter are not fully understood. We report here that TGF-β directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated T179 of SMAD3-mediated interaction with RNA-binding protein PCBP1. We show that TGF-β and EGF respectively induce SMAD3 and PCBP1 to colocalize in SC35-positive nuclear speckles, and the two proteins interact in the variable exon region of CD44 pre-mRNA to inhibit spliceosome assembly in favor of expressing the mesenchymal isoform CD44s over the epithelial isoform CD44E. We further show that the SMAD3-mediated alternative splicing is essential to the tumor-promoting role of TGF-β and has a global influence on protein products of genes instrumental to epithelial-to-mesenchymal transition and metastasis."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.09.013"xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Tripathi V."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Zhang Y.E."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Weigert R."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/author | "Sixt K.M."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/pages | "549-564"xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/title | "Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-beta."xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/27746021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27746021 |
| http://purl.uniprot.org/citations/27746021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27746021 |
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| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-27746021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27746021 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-27746021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27746021 |
| http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-27746021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27746021 |
| http://purl.uniprot.org/uniprot/#_A0A385KNS5-mappedCitation-27746021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27746021 |