| http://purl.uniprot.org/citations/27748732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27748732 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-terminal truncated form of a protein synthesis enzyme, tryptophanyl-tRNA synthetase (mini-WRS), is secreted as an angiostatic ligand. However, the secretion and function of the full-length WRS (FL-WRS) remain unknown. Here, we report that the FL-WRS, but not mini-WRS, is rapidly secreted upon pathogen infection to prime innate immunity. Blood levels of FL-WRS were increased in sepsis patients, but not in those with sterile inflammation. FL-WRS was secreted from monocytes and directly bound to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex to induce phagocytosis and chemokine production. Administration of FL-WRS into Salmonella typhimurium-infected mice reduced the levels of bacteria and improved mouse survival, whereas its titration with the specific antibody aggravated the infection. The N-terminal 154-amino-acid eukaryote-specific peptide of WRS was sufficient to recapitulate FL-WRS activity and its interaction mode with TLR4-MD2 is now suggested. Based on these results, secretion of FL-WRS appears to work as a primary defence system against infection, acting before full activation of innate immunity."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmicrobiol.2016.191"xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Choi J.J."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Jin M."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Jeon Y."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Rhee K.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Kim P."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Han B.W."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Shim H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Inn K.S."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Ahn Y.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Kwon N.H."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Kang E."xsd:string |
| http://purl.uniprot.org/citations/27748732 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |