| http://purl.uniprot.org/citations/27758879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27758879 | http://www.w3.org/2000/01/rdf-schema#comment | "In colorectal cancer, APC-mediated induction of unregulated cell growth involves posttranslational mechanisms that prevent proteasomal degradation of proto-oncogene β-catenin (CTNNB1) and its eventual translocation to the nucleus. However, about 10% of colorectal tumors also exhibit increased CTNNB1 mRNA. Here, we show in colorectal cancer that increased expression of ZNF148, the gene coding for transcription factor ZBP-89, correlated with reduced patient survival. Tissue arrays showed that ZBP-89 protein was overexpressed in the early stages of colorectal cancer. Conditional deletion of Zfp148 in a mouse model of Apc-mediated intestinal polyps demonstrated that ZBP-89 was required for polyp formation due to induction of Ctnnb1 gene expression. Chromatin immunoprecipitation (ChIP) and EMSA identified a ZBP-89-binding site in the proximal promoter of CTNNB1 Reciprocally, siRNA-mediated reduction of CTNNB1 expression also decreased ZBP-89 protein. ChIP identified TCF DNA binding sites in the ZNF148 promoter through which Wnt signaling regulates ZNF148 gene expression. Suppression of either ZNF148 or CTNNB1 reduced colony formation in WNT-dependent, but not WNT-independent cell lines. Therefore, the increase in intracellular β-catenin protein initiated by APC mutations is sustained by ZBP-89-mediated feedforward induction of CTNNB1 mRNA. Cancer Res; 76(23); 6877-87. ©2016 AACR."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-15-3150"xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Tessier A.J."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Merchant J.L."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Shah Y.M."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Sundaresan S."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Gyorffy B."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Hayes M.M."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Ocadiz-Ruiz R."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Kang A.J."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Saqui-Salces M."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Essien B.E."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Tsao A.C."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Photenhauer A."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/author | "Chavis A."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/pages | "6877-6887"xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/title | "Transcription Factor ZBP-89 Drives a Feedforward Loop of beta-Catenin Expression in Colorectal Cancer."xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/27758879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27758879 |
| http://purl.uniprot.org/citations/27758879 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27758879 |
| http://purl.uniprot.org/uniprot/#_A0A338P6K3-mappedCitation-27758879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27758879 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-27758879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27758879 |