| http://purl.uniprot.org/citations/27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27759037 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for tumor suppression during the early stages. However, the mechanism of functional switching of TGF-β is still unknown, and it is unclear whether inhibition of TGF-β signaling results amelioration or exacerbation of cancers. Here we show that the tumor suppressor p53 cooperates with Smad proteins, which are TGF-β signal transducers, to selectively activate plasminogen activator inhibitor type-1 (PAI-1) transcription. p53 forms a complex with Smad2/3 in the PAI-1 promoter to recruit histone acetyltransferase CREB-binding protein (CBP) and enhance histone H3 acetylation, resulting in transcriptional activation of the PAI-1 gene. Importantly, p53 is required for TGF-β-induced cytostasis and PAI-1 is involved in the cytostatic activity of TGF-β in several cell lines. Our results suggest that p53 enhances TGF-β-induced cytostatic effects by activating PAI-1 transcription, and the functional switching of TGF-β is partially caused by p53 mutation or p53 inactivation during cancer progression. It is expected that these findings will contribute to optimization of TGF-β-targeting therapies for cancer."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep35483"xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Itoh Y."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Kawarada Y."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Kawasaki F."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/author | "Fukuura K."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/pages | "35483"xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/title | "TGF-beta induces p53/Smads complex formation in the PAI-1 promoter to activate transcription."xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27759037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27759037 |
| http://purl.uniprot.org/citations/27759037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-27759037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27759037 |